控制眼睛表面疾病在玻璃眼镜治疗:一个系统的审查
Özlem Evren Kemer1, Priya Mekala2, Bhoomi Dave2,3
1Department of Ophthalmology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara 06800, Turkey.
Bioengineering (Basel, Switzerland)
|October 25, 2024
概括
使用含有甲 (BAK) 的青光眼滴患者经常患上眼皮表面疾病 (OSD). 切换到无防腐剂 (PF) 选项并使用环素A可以显著改善OSD症状.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 眼睛表面疾病 眼睛表面疾病
背景情况:
- 眼表面疾病 (OSD) 是使用长期局部药物治疗的青光眼患者常见的并发症.
- 玻璃眼滴中的甲化物 (BAK) 是OSD的重要贡献者.
- 管理OSD对于患者的坚持和生活质量至关重要.
研究的目的:
- 审查绿眼病患者的OSD的流行率和管理策略.
- 评估防腐剂和替代治疗对眼睛表面的影响.
- 确定OSD管理的有效多因素方法.
主要方法:
- 系统审查遵循系统审查和元分析 (PRISMA) 标准的首选报告项目.
- 评估活性成分和防腐剂对眼睛表面的影响.
- 评估无防腐剂 (PF) 替代品和辅助疗法的有效性.
主要成果:
- 含BAK的玻璃眼病药物显著恶化OSD,导致角膜染色和减少膜稳定性.
- 切换到PF配方或较少的细胞毒性防腐剂 (Polyquad®,SofZia®) 可以改善OSD症状.
- 辅助环素A显示出抗炎功效,并增强了膜的稳定性.
结论:
- 有效的OSD管理需要采用多因素的方法.
- 关键策略包括切换到PF或更少的细胞毒性玻璃眼药物.
- 辅助的环素A和早期的外科干预 (MIGS等) 它们是有益的.
相关概念视频
Open Angle Glaucoma: Treatment
397
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
397
Angle Closure Glaucoma: Treatment
441
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
441
Glaucoma: Overview
516
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
516
Accessory Structures of the Eye
1.5K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.5K


