在性结肠炎的内镜和组织学缓解中,CRP和FCP的比较值
Oguz Kagan Bakkaloglu1, Gozde Sen2, Nuray Kepil3
1Department of Gastroenterology, Kartal Kosuyolu High Specialization Education and Research Hospital, 34865 Istanbul, Turkey.
Diagnostics (Basel, Switzerland)
|October 25, 2024
概括
反应蛋白 (CRP) 和便calprotectin (FCP) 有效地预测了性结肠炎 (UC) 的内镜和组织学缓解. 对于CRP和FCP的新切线改善了UC缓解的预测率.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床生物标志物分析
背景情况:
- 之前的研究表明,C-反应蛋白 (CRP) <2.9 mg/L与CRP <5 mg/L相比,在性结肠炎 (UC) 中内镜缓解 (ER) 的优异预测因素.
- 便calprotectin (FCP) 与CRP结合用于评估UC中缓解的诊断实用性需要进一步的前性验证.
研究的目的:
- 为了前性地评估和比较CRP和FCP的最佳切断值,以预测无类固醇UC患者的内镜缓解 (ER) 和组织学缓解 (HR).
- 评估CRP和FCP在确定UC中活跃疾病的程度方面的表现.
主要方法:
- 对135名无类固醇UC患者的前性评估.
- 内镜缓解 (ER) 被定义为梅奥内镜子评分0-1.
- 组织学缓解 (HR) 由南希和盖博斯分数 (分别为<1和<2) 在七个结肠段中定义.
主要成果:
- 对于ER的最佳切断值是FCP 120μg/g和CRP 2.75 mg/L;ROC分析显示这两种标记的性能相似.
- 对于HR的最佳切线是FCP55μg/g和CRP2.1 mg/L.
- CRP预测了疾病的广泛性,而FCP没有. 结合CRP和FCP检测到约2/3的ER和约1/2的HR患者具有高特异性.
结论:
- 重新评估的CRP切线值 (ER: 2.75 mg/L,HR: 2.1 mg/L) 提供了与FCP相比的诊断贡献,用于预测UC中的ER和HR.
- 在识别活跃大肠炎中的近位疾病扩散方面,CRP比FCP更有效.
- 结合CRP和FCP可以提高UC缓解的预测率.
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