多发性骨髓瘤中的花形血细胞具有形态异质性
Hiroki Hosoi1,2, Misato Tane1, Makiko Sogabe1
1Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan.
Diagnostics (Basel, Switzerland)
|October 25, 2024
概括
血细胞中的花形核是多发性骨髓瘤中罕见的发现. 这一案例突显了多发性骨髓瘤中依赖位点的形态瘤异质性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 多发性骨髓瘤是一种血细胞恶性瘤.
- 血细胞中的花形核是一种不常见的形态特征.
- 瘤内部异质性在多发性骨髓瘤中得到认可.
研究的目的:
- 报告一种罕见的多发性骨髓瘤病例,具有形态异质性.
- 突出瘤采样地点在识别异质性的重要性.
- 讨论血细胞核中取决于位点的形态变异的含义.
主要方法:
- 一个88岁的男性患有关节瘤的病例报告.
- 关节骨质的活检分析揭示了具有圆核的血细胞.
- 骨髓检查显示有花形核的血细胞.
- 多发性骨髓瘤的诊断工作,包括人类T-lymphotropic病毒类型-1测试.
主要成果:
- 病人被诊断出患有多发性骨髓瘤.
- 根据活检部位观察到不同的血细胞形态.
- 关节骨质量显示圆形核,而骨髓显示花形核.
- 人类T-lymphotropic病毒类型-1是负的.
结论:
- 这个案例证明了多发性骨髓瘤的位点依赖的形态异质性.
- 骨髓等离子体细胞中存在的花形核是一个关键的发现.
- 了解形态变异对于准确诊断和多发性骨髓瘤的表征至关重要.
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