在COVID-19后的肺炎中,血液中乙氨基基蛋白很重要
Nicol Bernardinello1, Gioele Castelli1, Dylan Pasin1
1Respiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padova University Hospital, 35128 Padova, Italy.
在住院期间异氨基细胞的增加可能预测COVID-19肺炎后的肺损伤. 这一发现有助于识别患有肺部继发症风险的患者,改善COVID-19患者管理.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 由于SARS-CoV-2引起的严重肺炎仍然是一个全球性的健康问题,尽管疫苗开发.
- 预测COVID-19疾病严重程度和肺部并发症的预测因素对于患者管理和资源优化至关重要.
- 血液细胞计数为疾病评估提供了可访问和可重复的生物标志物.
研究的目的:
- 为了研究埃索诺菲尔在预测COVID-19疾病行为中的作用.
- 在计算机断层扫描 (CT) 后续检查中,探索作为肺部序列的预测因子的乙素水平.
- 确定易于测量的生物标志物,以评估COVID-19后的长期肺部健康.
主要方法:
- 在住院COVID-19患者中评估血液细胞计数和炎症标志物.
- 基线和住院期间收集大量患者队列的数据.
- 多变量分析以确定残留肺异常的独立预测因素.
主要成果:
- 分析了327名患者,分为低强度 (LIMC) 和高强度 (HIMC) 医疗保健组.
- 在HIMC组中,乙氨基基细胞计数在出院时显著更高 (p < 0.0001).
- 年龄≥62岁和色素 (Δ色素) ≥0.05的增加是残留肺异常的独立预测因子 (p=0.03).
结论:
- 住院期间异氨基细胞的增加是COVID-19幸存者的肺部连续病变的潜在预测因素.
- 乙氨基基基的动态可以帮助识别患有肺炎后持续性肺部问题的风险的患者.
- 这一发现支持使用血细胞计数来评估COVID-19恢复的预后.
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