微观结肠炎导致的慢性腹:一项对照研究,了解诊断挑战和问题的规模
Ahmed Ibrahim Gad1, Sara Mohamed Salem1, Hanaa A Nofal2
1Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Diagnostics (Basel, Switzerland)
|October 25, 2024
概括
微观性结肠炎 (MC) 是慢性腹的常见原因,通常通过结肠镜活检诊断. 像便calprotectin和ESR这样的炎症标志物是MC的宝贵诊断工具.
科学领域:
- 胃肠病学 胃肠病学
- 组织病理学 组织病理学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 微观性结肠炎 (MC) 是慢性腹的一个未被确诊的原因.
- 诊断往往需要对结肠镜活检进行组织病理学检查.
- 正常的结肠镜外观可以掩盖MC.
研究的目的:
- 为了准确地诊断慢性腹,使用组织病理学.
- 为了确定MC的流行率.
- 评估MC生物标志物的诊断实用性.
主要方法:
- 一项基于医院的队列研究,包括116名慢性腹患者.
- 用粘膜活检进行结肠镜检查.
- 便calprotectin (FC),ESR,CRP,便分析和临床数据的分析.
主要成果:
- 肌痛性结肠炎的患病率为32.8% (25.9%是淋巴细胞结肠炎,6.9%是质结肠炎).
- 升高的FC,ESR和CRP水平与MC有显著的关联.
- 夜间腹和腹痛是关键的临床指标.
- ESR (>14 mm/h) 和FC (>64 mcg/g) 显示出高的诊断准确性 (AUC为0.94和0.97).
结论:
- 淋巴细胞结肠炎,特别是淋巴细胞结肠炎,是慢性腹的常见原因.
- 像腹痛和夜间腹这样的症状需要对MC进行调查.
- 炎症标志物 (ESR,FC) 对MC诊断有用,但建议进行进一步的研究.
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