在接受免疫检查点抑制剂治疗的患者中管理选择性免疫相关不良事件
Parneet K Cheema1, Marco A J Iafolla1, Husam Abdel-Qadir2,3
1William Osler Health System, Brampton, ON L6R 3J7, Canada.
Current oncology (Toronto, Ont.)
|October 25, 2024
概括
与免疫相关的不良事件 (irAEs) 的标准化管理与免疫检查点抑制剂 (ICI) 的使用增加至关重要. 本研究概述了在癌症护理中早期识别,评估和治疗irAEs的实用,多学科方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
- 免疫相关不良事件 (irAEs) 需要标准化的监测和管理.
- 现有的指导方针提供了高级别的建议,但缺乏实际的机构指导.
研究的目的:
- 描述一种实际的,逐步的多学科方法来管理irAEs.
- 为照顾ICI患者的医疗保健提供者提供算法和建议.
- 促进早期识别,评估和治疗IRAE.
主要方法:
- 开发用于irAE管理的机构协议和算法.
- 加拿大各地多学科专家之间的合作.
- 基于irAE特征的基线调查,监测和治疗的详细概述.
主要成果:
- 在威廉·奥斯勒医疗系统开发了一个用于管理irAEs的实用框架.
- 该方法包括基线调查,监测和治疗策略.
- 建议是根据所涉及的症状,严重程度和器官系统量身定制的.
结论:
- 标准化,多学科的协议对于有效的irAE管理至关重要.
- 描述的方法可以被其他机构调整,以改善患者的护理.
- 及时和协作地管理irAEs对于患者的安全和治疗疗效至关重要.
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