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Updated: Jun 9, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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在韩国人脑内动脉瘤中的高流动性组盒蛋白1的基因基因关联研究

Eun Pyo Hong1, Sung Woo Han1, Bong Jun Kim1

  • 1Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon 24254, Republic of Korea.

Brain sciences
|October 25, 2024
PubMed
概括

这项研究发现,脑内动脉瘤 (IA) 和对照患者之间的高移动性组框1 (HMGB1) 中没有显著的遗传或表达差异,这表明HMGB1不是IA发展的主要遗传因素.

关键词:
血中的HMGB1蛋白水平.这是HMGB1基因的表达.头骨内动脉瘤是什么意思在HMGB1基因中存在变异.

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相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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