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反应性星细胞 - - 长期COVID-19患者自杀率增加的潜在因素?

Alessandra Costanza^1,2,3,4, Andrea Amerio^5,6, Andrea Aguglia^5,6

¹Department of Psychiatry, Faculty of Medicine, University of Geneva (UNIGE), 24 Rue du Général-Dufour, 1211 Geneva, Switzerland.

|October 25, 2024

概括

长期的COVID-19与由于天体细胞功能障碍而增加的自杀风险有关. 恢复星球细胞的健康可能会减轻这些严重的神经精神病学影响患者.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
精神病学是一个精神病学.

背景情况:

长期的COVID-19带来了严重的公共卫生挑战,包括神经精神病症状,包括自杀念头和行为 (SI/SB).
越来越多的证据表明,星细胞功能障碍与这些神经精神病的后果之间存在潜在联系.

研究的目的:

审查和综合临床证据关于星细胞功能障碍在长期COVID-19中的作用及其与自杀念头和行为的关联.
探索与天体细胞相关的病理作为抑郁症,SI/SB和COVID-19之间的共享机制.

主要方法:

临床证据的系统审查.
对检查天体细胞子组,蛋白质组/转录标记物和循环天体细胞相关标记物的研究进行分析.
在相关患者群体中检查反应性星细胞瘤的证据.

主要成果:

抑郁症和SI/SB与改变的天体细胞子集和特定区域的分子变化有关.
抑郁症和,在较小程度上,在COVID-19中观察到与天体细胞相关的循环标记的增加.
反应性星细胞瘤是SI/SB和COVID-19患者的常见发现.

结论:

星细胞功能障碍与抑郁症,SI/SB和COVID-19有关.
反应性星球细胞可能会损害血脑屏障的完整性,导致神经炎症和长期COVID-19中自杀风险增加.
针对天体细胞平衡,血脑屏障完整性和神经炎症的治疗策略是必要的,以解决长期COVID-19的神经精神病学表现.

关键词:

星球细胞是星球细胞.血脑屏障血脑屏障血脑屏障血脑屏障抑郁抑郁症抑郁症抑郁症抑郁症长时间的COVID-19 神经炎症是一种神经炎症.反应性星细胞形成.自杀行为自杀行为.自杀的想法自杀的想法

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