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脑动脉瘤启动过程的流体结构相互作用模拟

Jozsef Nagy¹, Wolfgang Fenz², Veronika M Miron³

¹eulerian-solutions e.U., Leonfeldnerstraße 245, 4040 Linz, Austria.

|October 25, 2024

概括

新的流体结构相互作用分析显示,低和高壁切削应力 (WSS) 和振荡切削指数 (OSI) 条件都会导致脑动脉瘤的发生和生长.

科学领域:

生物医学工程生物医学工程
计算流体动力学的流体动力学.
医学物理医学物理

背景情况:

脑动脉瘤生长的血液动力学仍然不太了解.
开发了一种新的流体结构相互作用 (FSI) 分析方法.
这种方法有助于识别动脉瘤发作的关键情景.

研究的目的:

为了研究脑动脉瘤发育期间的血液动力学条件.
为了确定与动脉瘤发作相关的不同血液动力学场景.
分析血液动力学变化随着动脉瘤的生长.

主要方法:

综合流体动力学和结构力学,用于全面的FSI分析.
包括单个,未破裂的大脑动脉瘤患者.
在动脉瘤发作区域 (RAO) 分析了墙壁剪切应力 (WSS) 和振荡剪切指数 (OSI).

主要成果:

确定了三个血液动力学场景 (A:低WSS/高OSI,B:高WSS/低OSI,C:混合).
结构力学显示了类似但独立的趋势.
在成长过程中,B情景中的动脉瘤转移到A (47%) 或C (20%);A和C保持稳定.

结论:

在脑动脉瘤中,WSS和OSI是相互调节的.
低和高WSS/OSI条件都可以启动动动脉瘤的形成.
血液动力学条件影响动脉瘤的进展和转变.

关键词:

大脑动脉瘤是什么意思流体结构相互作用模拟血液动力学血液动力学启动启动启动结构力学结构力学

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