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限制性立法如何影响从狗阴道中选择的细菌分离物的抗菌敏感性
Anna Sophia Leps1, Babette Klein2, Marianne Schneider2
1Unit for Reproductive Medicine-Clinic for Small Animals, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Antibiotics (Basel, Switzerland)
|October 25, 2024
概括
德国关于在养中使用抗微生物药物的立法显示出混合的结果. 虽然总体细菌敏感性有所改善,但观察到对某些抗生素 (如塞法列克辛) 的耐药性有所增加.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 抗微生物药物管理对于打击抗微生物药物耐药性至关重要.
- 在用于治疗不孕症的犬种繁殖中,预防性抗菌素的使用是常见的.
- 像德国的TÄHAV这样的限制性立法旨在改善管理.
研究的目的:
- 评估修订后的德国兽医家庭药房条例 (TÄHAV) 对抗菌素耐药性的影响.
- 为了比较在立法变化之前和之后的狗阴道隔离物中的细菌耐药性概况.
- 评估限制性立法在促进抗微生物药物管理方面的有效性.
主要方法:
- 分析了13373个从狗阴道抽样中获得的抗菌素敏感性测试.
- 包括分离物:大肠杆菌,β-溶血性链球菌和Staphylococcus intermedius组.
- 用于对纯种植物进行敏感性测试的微稀释方法.
主要成果:
- 在立法后,大肠杆菌易感性普遍增加,但对头素的不易感性显著增加 (p < 0.0001).
- 贝塔-溶血性链球菌对大多数测试的抗微生物药物保持了良好的敏感性.
- 在Staphylococcus intermedius组显示了两价易感性变化,与一些增加的非易感性.
结论:
- 修改后的TÄHAV对犬体阴道隔离物中的抗菌素敏感性产生了整体积极影响.
- 对特定抗微生物药物的不敏感性增加表明了潜在的限制或需要立法改进.
- 监测耐药性概况对于有效调整管理策略至关重要.
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