临重病患者的莱涅佐利德的药理动力学:连续或间歇性输液输注
Ligia-Ancuța Hui1,2, Constantin Bodolea2,3, Adina Popa4
1Pharmaceutical Technology and Biopharmacy Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", 400012 Cluj-Napoca, Romania.
与间歇输液 (II) 相比,对重症患者的连续输液 (CI) 减少了药物度的变化. 这可以通过保持最佳药物水平来提高安全性和临床结果.
科学领域:
- 药理动力学和药理动力学
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
背景情况:
- 莱涅佐利德在血度中表现出显著的个体间变化,特别是在重症患者中,可能导致低于最佳的治疗水平.
- 优化线索利德治疗的策略包括加重剂量,更高的维持剂量,剂量分层,治疗药物监测和连续输注 (CI) 与间歇输注 (II) 相比.
研究的目的:
- 在重症患者中,通过间歇性输注 (II) 与连续输注 (CI) 进行药理动力学 (PK) 参数比较.
- 根据不同的药理方法,根据药理动力学/药理动力学 (PK/PD) 指数评估linezolid的疗效.
主要方法:
- 一项在重症监护病房进行的前性研究,比较了通过II和CI给药的相同每日剂量的linezolid.
- 测量了血清度,并计算了PK参数.
- 主要的PK/PD疗效指数是稳定状态下度-时间曲线下的面积除以最小抑制度 (AUC24-48/MIC>80).
主要成果:
- 与间歇输液 (II) 相比,连续输液 (CI) 显示出明显较低的血清度变化.
- 目标%T>MIC>80%在CI时实现了100%的时间,MIC为1和2μg/mL,相比之下,II分别为93%和73%.
- AUC24-48/MIC> 80的目标在100%的CI病例中实现,而在II病例中达到87%的MIC为1μg/mL.
结论:
- 虽然这两种输液方法都是可比的,但CI提供了潜在的好处超过II通过避免药物度低于最佳水平,可能提高安全性和临床结果.
- 研究结果表明,CI可能是临界病患者用linezolid作为一种有价值的替代品,以确保持续治疗药物暴露.
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