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在面再生中对干细胞应用的系统审查

Man Hung^1,2,3,4,5, Mahsa Sadri¹, Melanie Katz¹

¹College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA.

Dentistry journal

|October 25, 2024

概括

中介细胞干细胞在面外科手术中显示出有前途的骨再生. 这次审查证实了它们的安全性和有效性,为改善外科手术结果铺平了道路.

科学领域:

再生医学是一种再生医学.
口腔和牙面部外科手术
干细胞疗法是一种干细胞疗法.

背景情况:

再生医学利用干细胞,特别是介质干细胞 (MSCs),用于口腔和面外科手术中的组织和骨再生.
虽然体外试验有希望,但人类临床试验仍然有限.
系统性审查至关重要,以评估MSC在面应用中的有效性.

研究的目的:

系统地审查干细胞治疗在口腔和面外科手术中的疗效和安全性.
评估干细胞在面缺陷中的组织和骨再生的潜力.
确定干细胞应用的当前趋势和结果,以改善外科手术结果.

主要方法:

系统审查遵循系统审查和元分析 (PRISMA) 准则的首选报告项目.
搜索了主要的数据库 (PubMed,科学网,Scopus等) 在2013年至2023年之间发表的同行评审文章.
包括专注于口腔外科干细胞的研究,由两位独立审稿人严格查和数据提取.

主要成果:

在选了3540篇初始文章后,有7项研究符合纳入标准.
主要使用的是介质细胞干细胞.
结果表明了积极的临床安全性和有效性,具有显著的骨再生和骨质改善潜力.

结论:

干细胞疗法,特别是使用MSCs,在面应用中显示出相当大的潜力.
该疗法得到了安全性,有效性和骨再生能力的证据的支持.
建议进行进一步的研究,以标准化协议并验证长期益处.

关键词:

骨再生骨再生文献审查文献审查口面部面部面部干细胞是干细胞的组成部分.组织再生组织再生

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