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在口腔状细胞癌中NTRK基因表达分析墨西哥人口墨西哥人口

Lilibeth Stephania Escoto-Vasquez¹, Javier Portilla-Robertson¹, Josué Orlando Ramírez-Jarquín²

¹Oral Medicine and Pathology Department, Postgraduate and Research Division, Dentistry School, National Autonomous University of Mexico, Mexico City 04510, Mexico.

Dentistry journal

|October 25, 2024

概括

在口腔状细胞癌 (OSCC) 中存在NTRK基因和Trk受体表达. 它们的差异表达与瘤等级相关,表明它们可能是口腔癌的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

口腔癌是一个重大的全球健康问题,口腔状细胞癌 (OSCC) 占病例的90%.
NTRK基因及其受体被认为是各种人类癌症的瘤发生和进展的关键调节者.

研究的目的:

研究OSCC中NTRK基因和Trk受体的表达.
分析墨西哥OSCC患者样本中NTRK/Trk表达和临床病理特征之间的关联.

主要方法:

使用软件辅助方法分析95例OSCC病例的泛土耳其免疫表达.
通过RT-qPCR使用ΔΔCT方法进行基因表达分析.
统计分析包括克鲁斯卡尔-瓦利斯和斯皮尔曼的相关性测试.

主要成果:

在年龄和瘤的解剖部位之间发现了显著的关联.
42%的病例是泛Trk阳性,在差异化不良的OSCC中观察到强烈的免疫表达,与年龄和性别相关.
在差异化不良的OSCC中,NTRK2的表达率更高,而在差异化良好的病例中,NTRK3的表达率明显更高.

结论:

在OSCC中证实了NTRK家族基因表达,与瘤分化程度相关的明显表达模式.
对NTRK激活或突变状态的进一步研究可以确定它们作为OSCC的治疗点的作用.

关键词:

俄罗斯国家广播电视台 (NTRK)RT-qPCRR 是一个人.相关性表达式是一种相关性表达式.免疫组织化学免疫组织化学全方位的TRK.

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