一个现实世界的纵向研究非功能性垂体附带瘤:一个PRECES微腺瘤子分析
Mihai Costachescu1,2,3, Claudiu Nistor3,4, Ana Valea5,6
1Department of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Diseases (Basel, Switzerland)
|October 25, 2024
概括
许多垂体瘤 (PIs) 随着时间的推移而生长,即使是小的瘤,也需要更长的监测. 诊断时的年龄不能预测这些非功能性微腺瘤的瘤生长.
科学领域:
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 由于先进的成像技术,全球偶发性瘤的发病率不断增加.
- 垂体附带瘤 (PIs) 是内分泌附带瘤的一个子集.
- 非功能性微腺瘤 (<1厘米) 是常见的PI.
研究的目的:
- 通过连续计算机断层扫描 (CT) 扫描来分析垂体附带瘤 (PI) 的动态变化.
- 评估最初诊断为非功能性微腺瘤的成年患者的生长模式.
- 为了确定影响PI大小随时间变化的因素.
主要方法:
- 成年患者 (20-70岁) 的多中心,纵向,回顾性研究.
- 纳入标准:非功能性小腺瘤 (<1厘米),没有荷尔蒙过量/不足.
- 排除标准:瘤大于1厘米,基线荷尔蒙功能障碍.
- 收集了关于瘤直径,随访时间和患者人口统计数据的数据.
主要成果:
- 包括117名成年患者 (94%为女性),平均年龄为43.86岁.
- 随访时间中位数为40个月;没有PI变得功能或超过1厘米.
- 在随访期间,39.32%的患者显示PI直径增加.
- 增加直径的组具有较小的初始尺寸和更长的监测期.
- 最初的瘤大小,而不是年龄,影响了生长潜力.
结论:
- 在延长的随访期内,显著比例的垂体附带瘤的直径可能会增加.
- 较小的初始瘤大小与更高的生长可能性有关.
- 诊断时的年龄不是PI中瘤生长的预测因素.
- 结果可能会为 pituitary incidentalomas 的长期监测方案提供信息.
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02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...