炎症性前列腺炎加IBS-D亚型和与精液等离子体中免疫调节剂不平衡的相关性:新的联合治疗方法
Roberto Castiglione1, Gaetano Bertino1, Beatrice Ornella Vicari2
1Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Diseases (Basel, Switzerland)
|October 25, 2024
概括
利法西明和De Simone配方 (DSF) 益生菌显著改善了慢性前列腺炎和IBS-D患者的症状. 治疗还减少了精液等离子体中的促炎性IL-6和增加了抗炎性IL-10.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
背景情况:
- 慢性炎症性前列腺炎 (IIIa前列腺炎) 和腹占主导地位的刺激性肠综合征 (IBS-D) 经常同时发生.
- 肠道和前列腺的轻度炎症可能是IIIa前列腺炎和IBS-D的共同病变的基础.
研究的目的:
- 评估联合利法西明和De Simone配方 (DSF) 益生菌治疗IIIa前列腺炎和IBS-D患者的疗效.
- 评估这种联合治疗对精液等离子体前炎性 (IL-6) 和抗炎性 (IL-10) 细胞因子的影响.
主要方法:
- 124名患有IIIa前列腺炎和IBS-D的患者被随机分为两组.
- 组A (n=64) 接受了利法西明和DSF;组B (n=60) 接受了安慰剂.
- 在治疗前和治疗后测量了NIH-CPSI,IBS-SSS和精液血细胞因子水平.
主要成果:
- 与安慰剂组相比,A组的NIH-CPSI (68.7%) 和IBS-SSS (62.5%) 评分显著改善,分别为3.3%和5%).
- 在A组,精液血IL-6水平显著下降 (11.3比32.4ppg/ml),IL-10水平显著增加 (7.9比4.4ppg/ml).
- 在安慰剂组中没有观察到IL-6和IL-10水平的显著变化.
结论:
- 联合利法西明和DSF治疗对同时发生的IIIa前列腺炎和IBS-D的管理是有效的.
- 这种治疗方法对于具有复杂症状表现的多因素疾病特别有益.
- 该疗法调节精液等离子细胞因子,表明对局部炎症过程的影响.
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