在成人心理健康环境中对药基因组 (PGx) 测试的实施进行规范化:基于理论的系统审查
Adam Jameson1,2,3, Justine Tomlinson2, Kristina Medlinskiene2,4
1Bradford District Care NHS Foundation Trust, Bradford BD18 3LD, UK.
Journal of personalized medicine
|October 25, 2024
概括
药基因组 (PGx) 测试提供个性化精神病学处方,但实施面临知识差距和政策不确定性等障碍. 解决这些因素是改善心理健康护理患者结果的关键.
科学领域:
- 精神病学药物基因组学
- 实施科学 实施科学
- 心理健康治疗 心理健康治疗
背景情况:
- 药物遗传学 (PGx) 测试有可能个性化精神病学处方,超越传统的试错方法.
- 尽管具有潜力,但PGx在精神病学中的广泛临床应用仍然有限.
- 了解影响PGx采用的因素对于其成功融入精神病学实践至关重要.
研究的目的:
- 系统地审查和综合现有关于影响精神病学中药物基因组测试实施因素的文献.
- 以规范化过程理论 (NPT) 为框架,确定PGx实施的关键障碍和促进因素.
主要方法:
- 在四个数据库中进行了系统的文献搜索,遵守PRISMA指南.
- 包括的记录使用QuADS工具进行了质量评估.
- 在"不扩散核武器条约"的指导下,采用了主题分析来确定障碍和促进主题.
主要成果:
- 在合成中包含了29个记录.
- 确定的主要障碍包括专业人士之间的PGx知识差距,缺乏政策共识,以及关于PGx实用性的不确定性.
- 促进者包括对PGx作为一种改进的处方方法的兴趣,多学科合作的价值,以及需要支持性的实施气候.
结论:
- 审查强调需要国家政策和专门的心理健康专业人员教育/培训计划,以促进PGx的实施.
- 解决已识别的障碍和利用促进者可以帮助弥合精神病学PGx实施差距.
- 未来的研究应该集中在评估PGx实施和药剂师在开发和提供PGx服务方面的作用,以推进个性化精神药物处方.
关键词:
在PGx测试中进行PGx测试.实施科学 实施科学心理健康 心理健康个性化药物是个性化的药物.提供个性化的处方.药物遗传学 药物遗传学药物基因组学 药物基因组学精准医学是一门精准医学.精神病学是一种精神病学.系统性审查 系统性审查更多相关视频
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