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Updated: Jun 9, 2025

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Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy

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在体内诱导化疗敏感化的理论模型,使用包装在不同的分层脂质体中的miRNA

Ruxandra-Ioana Cipu1, Mihai-Laurențiu Stănişteanu1, Mihaela-Aurelia Andrei1

  • 1Department of Biomaterials and Medical Devices, Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.

Journal of functional biomaterials
|October 25, 2024
PubMed
概括

这项研究提出了一种基于脂质体的新型基因传递系统,以克服化疗耐药性. 该系统抑制药物代谢酶,使更便宜的药物能够使用,并改善患者的治疗结果.

关键词:
癌症 癌症 癌症 癌症化疗 化疗是一种化学疗法.代谢 代谢 代谢 代谢治疗效率 治疗效率 治疗效率

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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