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基胺胺氨基基树脂:对强度,表面性能,抗真菌活性的影响,以及在基分子对接分析中

Sarah Aldulaijan¹, Raghad Alruwili², Rawan Almulaify²

¹Chemistry Department, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Journal of functional biomaterials

|October 25, 2024

概括

添加二甲二甲氨基化物 (C₁₂BDMA-Cl) 给基于假牙的树脂 (DBR) 显示了对Candida albicans的抗真菌特性. 这种新方法可以改善假牙口炎的管理,而不会影响机械性能.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
菌类学菌类学是指菌类学.

背景情况:

假牙口腔炎通常是由粘附于基于假牙的树脂 (DBRs) 的Candida albicans引起的.
将抗菌剂纳入DBR是一种新的预防假牙口腔炎的策略.
甲化 (C₁₂BDMA-Cl) 在DBRs中的抗真菌功效以前没有被研究过.

研究的目的:

评估用C₁₂BDMA-Cl.修改的DBRs的机械性能和抗真菌活性.
评估C₁₂BDMA-Cl结合对DBRs物理特性的影响.
调查C₁₂BDMA-Cl作为预防假牙口腔炎的抗真菌剂的潜力.

主要方法:

商用热聚合烯酸DBR被修改为3%和5%的C12BDMA-Cl.
测试了机械性能 (屈曲强度,弹性模量,微硬度,表面粗度).
使用Candida albicans生物膜测定 (CFU,SEM) 和in silico分子对接来评估抗真菌功效.

主要成果:

含有3%的C12BDMA-Cl的DBRs对Candida albicans表现出显著的抗真菌活性.
加入3%的C₁₂BDMA-Cl并没有对DBR的机械性能产生负面影响.
在SEM分析中,C₁₂BDMA-Cl修改DBRs上的Candida albicans殖民减少.

结论:

C₁₂BDMA-Cl是一种对DBRs有前途的抗菌剂.
修改后的DBR显示出预防和管理假牙口腔炎的潜力.
进一步的研究可以探索C₁₂BDMA-Cl在牙科假肢中的临床应用.

关键词:

烯酸是一种这是一种抗真菌药物.生物活跃的生物活性.假牙是一种假牙.树脂树脂是一种树脂.

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