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在档案和当代Bacillus cereus组基因组中调查炭相关的病毒性基因

Susanna J Sabin¹, Cari A Beesley², Chung K Marston²

¹Laboratory Leadership Service Fellow Assigned to the National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA 30329, USA.

Pathogens (Basel, Switzerland)

|October 25, 2024

概括

细菌类群 (BCG) 中的炭病毒性基因很可能是从共同的祖先中继承的,随后在某些血统中发生基因丢失. 这影响了炭病的定义和监测策略.

科学领域:

基因组学就是基因组学.
微生物学微生物学
进化生物学进化生物学

背景情况:

炭杆菌通过等离子体编码的毒性因子引起炭.
相关的Bacillus cereus群 (BCG) 生物可以获得炭病毒性基因,使疾病的定义复杂化.
了解BCG中的基因获取和进化对于公共卫生至关重要.

研究的目的:

在Bacillus cereus群体内调查炭病相关毒性基因的进化史.
分析非B.的全基因组序列. 炭虫BCG分离物检测病毒性基因获取的证据.
为了澄清基因遗传与水平基因转移在毒性基因分布中的作用.

主要方法:

98个非B的全基因组测序. 炭虫BCG分离物 (93个档案,5个当代).
创建注释的基因组组合.
全基因组分析以确定同源和获得的毒性基因.

主要成果:

十个BCG分离物含有至少一个与炭病相关的毒性基因.
在档案分离物中,同源的毒性基因序列经常显示出伪基因化和基因丢失.
辅助基因的分布,包括病毒性基因,与BCG核心基因组原型相关.

结论:

与炭病相关的毒性基因很可能是从一个共同的BCG祖先中继承的.
基因在BCG谱系中的保留或丢失解释了当前的毒性基因分布.
调查结果为炭病监测和鉴定策略提供了信息.

关键词:

百日 (Bacillus anthracis) 是一种植物.百日谷类小麦 (Bacillus cereus) 的一个群体.炭病是一种炭病.基因衰变的基因衰变基因组学就是基因组学.伪基因伪基因伪基因伪基因

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