与抗生素结合的菌体疗法:对抗多药耐药格兰氏阴性病原体的有希望的替代方案
Cleo Anastassopoulou1, Stefanos Ferous1, Aikaterini Petsimeri1
1Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Pathogens (Basel, Switzerland)
|October 25, 2024
概括
菌体疗法为抗生素提供了一个有希望的替代品,用于对抗耐药细菌,如Klebsiella pneumoniae,Pseudomonas aeruginosa和Acinetobacter baumannii. 本综述探讨了其在临床应用中的潜力和挑战.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 生物技术是生物技术.
背景情况:
- 抗菌素耐药性 (AMR) 是一个全球公共卫生危机.
- 菌体 (菌体) 是感染细菌的病毒,可以用于治疗.
- 菌体疗法有着悠久的使用历史,特别是在东欧,并且在美国正在出现慈悲护理.
研究的目的:
- 审查菌体疗法的临床前和临床应用,以对抗关键的格拉姆阴性病原体.
- 讨论使用菌体作为AMR感染的替代或辅助治疗的优点和挑战.
- 要突出使用适应性菌体种群与抗生素一起用于对抗不断发展的细菌的复杂性.
主要方法:
- 关于临床前研究,临床报告和随机临床试验的综合文献综述.
- 专注于针对Klebsiella pneumoniae,Pseudomonas aeruginosa和Acinetobacter baumannii的菌体治疗应用.
- 对菌体与抗生素相互作用及其对细菌毒性和耐药性的影响的分析.
主要成果:
- 临床前和临床证据支持菌体在治疗多抗药性细菌感染中的有效性.
- 菌体通过改变细菌结构,显示出逆转抗生素耐药性和增强抗微生物疗效的潜力.
- 菌素耐药菌株的出现是一个挑战,但菌素适应性提供了治疗优势.
结论:
- 菌体治疗,特别是与抗生素结合使用,是打击抗菌素耐药性传播的可行策略.
- 需要进一步的研究,以解决广泛临床应用的剩余挑战.
- 基于菌体的治疗方法为管理复杂的细菌感染提供了强大的工具.
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