螺旋体病-微生物群相互作用:系统性审查和元分析
Philip Afful1, Godwin Kwami Abotsi1, Czarina Owusua Adu-Gyamfi1
1Biomedical and Clinical Research Centre, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Pathogens (Basel, Switzerland)
|October 25, 2024
概括
杆菌病显著改变宿主微生物群,增加对细菌感染的易感性. 结合益生菌的治疗可以通过恢复微生物平衡来减少疾病的严重程度.
科学领域:
- 微生物组研究 微生物组研究
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
背景情况:
- 全球有数以百万计的人患有虫病,由寄生虫平虫 (如Schistosoma mansoni和S. haematobium) 引起.
- 肠道和泌尿道微生物群在杆菌病易感性中起作用,但这种相互作用尚未完全理解.
- 这项研究系统地审查了杆菌病和宿主微生物群之间的关系.
研究的目的:
- 探索杆菌病与宿主微生物群之间的复杂关系.
- 提供有关疾病病原和管理策略的关键见解.
- 分析不同类型的schistosoma和praziquantel治疗对微生物群的影响.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在多个数据库和谷歌学者中搜索相关的同行评审文章.
- 使用Meta-Mar v3.5.1进行分析,包括随机效应模型和子组分析;使用科克兰的Q测试和希金斯的I2统计学评估异质性.
主要成果:
- 在各种样本类型 (血液,便,尿液等) 中,发现了杆菌病与改变宿主微生物组之间的显著关联. ) 的情况.
- S. haematobium和S. mansoni感染,以及实验量治疗,显著促进了微生物组变化的异质性.
- 无论是男性还是女性,schistosoma感染都显示出更高的改变宿主微生物组的风险.
结论:
- 杆菌病破坏宿主微生物群,增加对机会性细菌病原体的易感性,如大肠杆菌和Klebsiella.
- 微生物组的破坏有助于炎症和疾病的进展;需要针对性别的方法来管理FGS.
- 与益生菌相结合的普拉齐昆治疗可以通过解决微生物组失衡来减轻疾病的严重程度.
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