微RNA生物发生,基因调控机制,以及在食品中的可用性
Amilton S de Mello1, Bradley S Ferguson2, Erica L Shebs-Maurine1
1Department of Agriculture, Veterinary and Rangeland Sciences, University of Nevada, Reno 1664 N. Virginia St. Mail Stop 202, Reno, NV 89557, USA.
Non-coding RNA
|October 25, 2024
概括
食物衍生的microRNAs (miRNAs) 在肠道中被吸收,可能会影响宿主基因表达和新陈代谢. 本综述探讨了精密营养应用中的miRNA生物发生,基因调节和饮食生物可用性.
科学领域:
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 营养科学 营养科学
背景情况:
- 微RNA (miRNA) 是小型的非编码RNA,在转录后调节基因表达.
- 新兴证据表明,饮食中的miRNAs是生物可用的,并在胃肠道 (GIT) 中被吸收.
- 这些外源miRNAs可能与宿主基因相互作用,影响表观遗传修饰和宿主代谢.
研究的目的:
- 审查miRNAs的生物发生和调节机制.
- 总结来自动物和植物来源的食品衍生的miRNAs的生物可用性.
- 讨论外源miRNAs在精密营养和健康调制中的影响.
主要方法:
- 关于miRNA生物发生和功能的文献综述.
- 在GIT中对miRNA吸收和生物可用性的研究分析.
- 对饮食中的miRNAs对宿主代谢的表观遗传影响的研究综合.
主要成果:
- miRNAs通过mRNA降解或翻译抑制来调节基因表达.
- 来自食物的miRNAs可以在消化过程中存活下来并被吸收,达到全身循环.
- 外源的miRNA具有诱导影响宿主生理学的表观遗传变化的潜力.
结论:
- 饮食中的miRNAs代表了宿主基因相互作用和代谢调节的新奇因素.
- 了解食物miRNAs的生物可用性和影响对于开发精密营养策略至关重要.
- 需要进一步的研究来阐明外源miRNA对人类健康的影响的全部范围.
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