关于海绵衍生的迪特尔的审查:2009-2022年
Jinmei Xia1, Xiangwei Chen1,2, Guangyu Li1
1Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.
Marine drugs
|October 25, 2024
概括
海洋海绵产生许多生物活性化合物,特别是二类. 本综述涵盖了来自海绵的228种二烯 (2009-2022年),其中许多显示出显著的制药潜力,特别是细胞毒性.
科学领域:
- 海洋天然产品 化学 化学
- 药理学是指药理学,即药理学是指药理学.
- 药用化学 医学化学
背景情况:
- 海洋海绵是具有制药应用的二次代谢物的丰富来源.
- 化物和化物是海绵中发现的主要生物活性化合物.
- 迪特尔类代表了这些海绵衍生的天然产品的重要群体.
研究的目的:
- 审查2009年至2022年间从海洋海绵中分离出来的二烯的结构和生物活动.
- 为了确定哪些海绵属是最丰富的二基化合物来源.
- 为了突出海绵衍生型二甲的药用潜力.
主要方法:
- 2009年至2022年科学出版物的文献综述.
- 收集和分析了33多种海绵属中分离的二烯数据.
- 与已识别的二烯相关的生物活动的分类.
主要成果:
- 总共有228种二烯被识别和审查.
- 发现 *Spongia* 属是最富有生产力的,占据了报告的四类动物的 27%.
- 在228种二烯中,有110种表现出各种生物活性,包括细胞毒性 (占总量的24%),抗菌,抗真菌,抗寄生虫,抗炎和抗物质.
结论:
- 海洋海绵,特别是*Spongia*属的海绵,是结构多样化的四面体的丰富来源.
- 显著的比例的这些diterpenoids拥有强大的生物活动,细胞毒性是最常见的.
- 由海绵衍生出的双体代表了一种有价值且在很大程度上尚未开发的资源,用于发现新的制药剂.
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