来自Skipjack金枪鱼框架的生物减轻了卵巢切除术诱导的骨质疏松病老鼠的骨损失
Jirakrit Saetang1, Acharaporn Issuriya2, Watcharapol Suyapoh3
1International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand.
Marine drugs
|October 25, 2024
概括
鱼类衍生生物从 skipjack 鱼的框架显示承诺骨质疏松症的预防. 这种天然源有效地对抗卵巢切除的老鼠的骨损失,为传统治疗提供了潜在的替代方案.
科学领域:
- 生物化学 生物化学
- 整形外科 整形外科 整形外科
- 营养科学 营养科学
背景情况:
- 骨质疏松症是一个重大的公共卫生挑战,其特点是骨质减少和骨折风险增加.
- 目前治疗骨质疏松症的方法存在局限性,这推动了对新型有效治疗剂的研究.
- 从鱼中获得的生物是骨健康的高度生物可用的潜在来源.
研究的目的:
- 为了研究从跳金枪鱼框架中获得的生物在预防骨质损失的有效性,在骨质疏松症的老鼠模型中.
- 为了比较金枪鱼生物与碳酸和雌激素治疗的骨保护作用.
主要方法:
- 鱼生物被提取并使用酶性水解,脱脂,漂白和研磨来净化.
- 使用Caco-2细胞单层模型评估的生物可用性.
- 卵巢切除术 (OVX) 的老鼠被分为两组,在8周内不接受任何治疗,雌激素,碳酸或鱼生物.
主要成果:
- 与碳酸 (10%) 相比,鱼生物在体外显示的吸收率更高 (13%).
- 与OVX组相比,金枪鱼生物显著增加了股骨 (26%) 和骨 (29%) 的骨量/组织体积 (BV/TV).
- 用金枪鱼生物的治疗导致了轨道的厚度增加,并且大腿骨和骨骨质细胞数量显著减少.
结论:
- 在卵巢切除的老鼠模型中,从 skipjack 鱼骨架中获得的生物有效地减轻了骨损失.
- 与碳酸相比,金枪鱼生物具有更高的生物可用性和骨保护作用.
- 这种鱼类生物是一种有希望的天然替代品,用于骨质疏松症的管理和预防.
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