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代谢学方法在牛奶样本中识别急性和亚急性乳腺炎的生物标志物:试点病例对照研究

Paola Quifer-Rada^1,2,3, Laia Aguilar-Camprubí¹, Sara Samino^3,4

¹LactApp Women Health, 08014 Barcelona, Spain.

|October 25, 2024

概括

哺乳乳乳腺炎涉及母乳中的代谢变化. 胆固醇和特定脂肪酸作为检测急性和亚急性乳腺炎的生物标志物具有前途.

科学领域:

生物化学生物化学
人体生理学人体生理学
哺乳期生物学哺乳期生物学

背景情况:

乳腺炎是母乳养的一个严重并发症,经常导致停止母乳养.
乳腺炎的确切原因和诊断仍然复杂且不完全理解.
确定乳腺炎的可靠生物标志物对于及时干预至关重要.

研究的目的:

为了研究急性和亚急性乳腺炎期间母乳中的代谢和脂质变化.
为了确定潜在的生物标志物用于早期检测乳腺炎.
了解与母乳养母亲乳腺炎相关的生化变化.

主要方法:

一项试点病例控制研究,涉及14名急性乳腺炎,32名亚急性乳腺炎和19名对照参与者.
质子核磁共振 (H-NMR) 光谱用于牛奶样本的代谢学分析.
多重调整后勤回归模型来评估代谢物/脂质和乳腺炎发展之间的关联.

主要成果:

质子NMR识别和量化了母乳中的40种代谢物.
急性乳腺炎显示与乙酸盐,总胆固醇,化胆固醇和斯芬戈美林有显著的关联.
亚急性乳腺炎与谷氨酸,溶酸乙醇,酸乙醇,等离子素和多不和脂肪酸有关;胆固醇与此有很强的关联.

结论:

在急性和亚急性乳腺炎期间,在母乳中明显出现代谢变化.
在乳腺炎中,乙酸盐,化胆固醇,lysophosphatidylcholine和多不和脂肪酸的含量都增加了.
乳腺炎的候选生物标志物包括胆固醇,酸醇,酸醇,等离子素和多不和脂肪酸.

关键词:

生物标志物生物标志物母乳养母乳养哺乳人类母乳是人类的母乳.脂质组的类型是什么乳腺炎是一种乳腺炎.

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