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Alexander G Masyutin^1,2, Ekaterina K Tarasova², Daniil A Samsonov¹

¹Department of Cell Biology and Histology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119991, Russia.

Nanomaterials (Basel, Switzerland)

|October 25, 2024

概括

工业多壁碳纳米管 (ig-MWCNTs) 被巨细胞显著降解. 细胞内和细胞外的ig-MWCNT都经历生物降解,为纳米材料安全提供了洞察力.

科学领域:

纳米材料科学是一门学科.
细胞生物学细胞生物学
毒理学毒理学毒理学

背景情况:

工业多壁碳纳米管 (ig-MWCNTs) 是普遍存在的,但它们被细胞生物降解仍未得到充分研究.
现有的研究主要集中在实验室级的MWCNT,忽视了工业变体的异质性.

研究的目的:

为了研究ig-MWCNTs由亲炎性巨细胞的生物降解.
分析ig-MWCNTs的细胞外和细胞内降解途径.

主要方法:

用两种类型的ig-MWCNT化人类 (THP-1) 和小鼠 (RAW264.7) 巨细胞10天.
使用传输电子显微镜,电子衍射,能量分散式X射线光谱和拉曼光谱分析纳米粒子定位,超结构和化学变化的分析.

主要成果:

细胞内和细胞外的ig-MWCNT都显示出相当大的生物降解.
细胞内ig-MWCNTs被穿孔并减少到石墨烯片.
细胞外的ig-MWCNTs表现出稀释作为降解机制.

结论:

巨细胞通过不同的细胞内和细胞外机制有效地生物降解ig-MWCNTs.
在ig-MWCNT降解中观察到的变异性表明设计具有量身定制的生物降解特性的纳米材料的潜力.

关键词:

在 MWCNT 中使用.生物降解生物降解工业级的多壁碳纳米管.有关炎症的巨细胞.

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