左心室扩张性功能障碍与升高的填充压力有关于源不明的栓塞性中风和心房动
Zubair Bashir1, Liqi Shu2, Yuqian Guo3
1Department of Cardiology, University of Texas Medical Branch, Galveston, TX 77555, USA.
概括
左心室扩张性功能障碍与升高的填充压力显示出与源不明的栓塞性中风 (ESUS) 的边缘关联,以及与ESUS患者中心房的检测有显著的联系. 这表明LVDD可能有助于识别患有隐性AF的中风患者.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 左心室扩张功能障碍 (LVDD) 和左心室填充压力升高 (LVFP) 预测结果,但它们在源不明的栓塞性中风 (ESUS) 中的作用尚不清楚.
- 这项研究调查了与非心血管血栓性中风 (NCE) 相比,ESUS中高LVFP的LVDD的患病率及其与心房动 (AF) 检测的关联.
研究的目的:
- 为了确定高LVFP的LVDD是否在ESUS患者中比NCE患者更常见.
- 在随访期间评估LVDD与高LVFP之间的关联,以及ESUS患者中检测到心房动 (AF) 的相关性.
主要方法:
- 在2016年1月至2017年6月期间,对509名成人缺血性中风患者 (ESUS和NCE) 进行了回顾性分析.
- 通过TTE评估左心室功能;中风病因由神经病学家判断.
- 多变量回归模型用于分析透支功能障碍,ESUS和AF检测之间的关联.
主要成果:
- 单独的LVDD与ESUS (aOR: 1.43,p=0.130) 或AF检测 (aOR: 1.88,p=0.179) 没有显著的关联.
- 带有高LVFP的LVDD显示出与ESUS的边界关联 (aOR:2.17,p=0.054).
- 带有高LVFP的LVDD与AF检测有显著的相关性 (aOR:3.59,p=0.038).
结论:
- 带有高LVFP的LVDD与ESUS边界相关,并且与AF检测有显著的关联.
- 识别高LVFP的LVDD可能有助于识别ESUS患者的潜在隐性心房动 (心房心脏病).
- 需要进一步的研究来证实这些发现并评估ESUS患者的抗凝策略,这些患者患有LVDD和升高的LVFP.
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