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在真实世界中使用毒素注射:来自法国的一项基于人口的研究

Alain Ruffion¹, Pierre Karam², Anne Forestier³

¹Department of Urology, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre-Bénite, France.

|October 25, 2024

概括

毒素A (BoNT-A) 注射常见于过度活动的膀和神经性失禁. 现实数据显示,注射间隔和数量各不相同,一般耐受性良好,但罕见的不良事件.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
药理学药理学是指药理学的学科.
现实世界的证据研究研究.

背景情况:

毒素A (BoNT-A) 的内毒素注射是针对异常性过活性膀 (iOAB) 和神经性毒素过活性失禁 (NDOI) 的已确立的治疗方法.
了解现实世界的使用模式和结果对于优化患者护理至关重要.

研究的目的:

分析在2014年至2022年间不 incontinence 治疗中使用 BoNT-A 的 intradetrusor 的现实趋势.
描述患者的人口统计,注射频率和与BoNT-A治疗相关的不良事件.

主要方法:

法国国家医院出院数据库 (PMSI) 的回顾性分析.
包括32,864名接受至少一种内突变体BoNT-A注射的患者.
根据适应症对患者的分类:IOAB,NDOI和其他.

主要成果:

大多数患者 (55.7%) 有IOAB,其次是NDOI (40.7%).
平均注射间隔因病情而异,从8.7个月 (多发性硬化症) 到11.5个月 (大脑病理).
一般来说,BoNT-A的耐受性很好;感染 (3.8%) 和出血 (0.11%) 等不良事件很少发生,并且在注射后早期发生.

结论:

现实世界的数据显示了 BoNT-A 注射频率和间隔的各种做法.
该疗法在各种失禁症候群中表现出良好的安全性.
进一步的研究可能会根据特定的患者群体和结果来改进治疗方案.

关键词:

肉毒毒素是一种毒素.护理途径的护理途径在内部食者食者神经系统疾病神经系统疾病过度活动的膀

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