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Updated: May 5, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
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High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

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从DNA编码的化学图书馆选中,SARS-CoV-2的宏环非共价抑制剂的理性设计Mpro从DNA编码的化学图书馆选中,证明了对泛冠状病毒同类物和耐尼马特里尔维尔抗性变种的强有力的抑制

Xu Wang1, Dimitar Gotchev1, Kristi Yi Fan1

  • 1Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States.

Journal of medicinal chemistry
|October 25, 2024
PubMed
概括

研究人员开发了一种新型非共价主蛋白酶 (Mpro) 抑制剂,有效对抗耐尼马特里尔维尔抗性SARS-CoV-2变体. 这种新化合物对其他冠状病毒也表现出广泛的活性,解决了关键的未满足的医疗需求.

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