孕期糖尿病和未来的心血管疾病:由性别特异性遗传数据的关联
Yeshen Zhang1,2,3, Shijie Yu4, Ziying Chen5,6
1Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
European heart journal
|October 25, 2024
概括
孕期糖尿病与女性冠状动脉疾病风险有明显的因果关系,这种风险是由2型糖尿病和高血压介导的. 针对这些因素可能会降低心血管疾病的风险.
科学领域:
- 心血管流行病学心血管流行病学
- 生殖内分泌学 生殖内分泌学
- 遗传流行病学遗传流行病学
背景情况:
- 孕期糖尿病 (GDM) 与心血管疾病 (CVD) 风险增加有关,但因果关系尚不确定.
- 门德尔随机化 (MR) 可以调查遗传倾向和因果关系.
- 性别分析对于理解GDM-CVD关系至关重要.
研究的目的:
- 调查GDM和心血管疾病风险的遗传倾向之间的因果关系.
- 探索GDM-CVD通路中的潜在调解因素.
- 利用大规模的全基因组关联研究 (GWAS) 数据进行可靠的推断.
主要方法:
- 采用了两个样本的MR和链接不平衡得分回归 (LDSC).
- 使用两步MR方法进行调解分析.
- 进行了灵敏度分析,以评估性和确认因果关系.
主要成果:
- LDSC揭示了GDM和冠状动脉疾病 (CAD) /常孕女性心肌梗塞之间的显著遗传相关性.
- 核磁共振分析表明,对GDM的遗传倾向对CAD风险具有诱导性因果作用 (OR:1.09,95%CI:1.01-1.17).
- 2型糖尿病和高血压被确定为GDM-CAD关联的显著调解者.
结论:
- 在GDM的遗传倾向和增加的CAD风险之间存在一种可暗示的因果关系.
- 2型糖尿病和高血压调解了这种关系.
- 针对可修改的心脏代谢风险因素可能会减轻女性有史以来GDM的CAD风险.
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