相关实验视频

Updated: Jun 9, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

针对线粒体的伊卡里纳米颗粒诱导免疫细胞死亡在肝细胞癌

Siyu Chen¹, Yiyang Sun¹, Yangla Xie²

¹The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou 310053, China.

ACS applied materials & interfaces

|October 25, 2024

概括

这项研究开发了新型纳米颗粒,以改善肝细胞癌 (HCC) 治疗的Icaritin (ICT) 输送. 新的配方增强了ICT的功能.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

肝细胞癌 (HCC) 是一种抗常规疗法的恶性瘤.
传统中医药中的伊卡里 (ICT) 通过诱导髓和免疫细胞死亡 (ICD) 显示出对HCC免疫疗法的前景.
信息通信技术的生物可用性较差限制了其治疗效果.

研究的目的:

开发和评估聚二氧化-N,N-乙胺) 乙基甲酸-b-聚-ε-烯酸氨 (OPDEA-PCL) 纳米颗粒,以提高HCC的ICT交付能力.
评估OPDEA-PCL/ICT纳米颗粒在促进ICD和全身抗癌免疫力方面的有效性.

主要方法:

将ICT封装到OPDEA-PCL共聚物中以形成纳米粒子 (ICT NP).
在实验室评估OPDEA-PCL/ICTNP与线粒体的同位化和小鼠HCC H22细胞中的ICD诱导.
在小鼠HCC模型中对OPDEA-PCL/ICTNP的瘤积累,系统性免疫性激活,瘤抑制和生存率的体内评估.

主要成果:

OPDEA-PCL/ICT NPs有效地与线粒体结合,增强ICT在H22细胞中的ICD诱导.
静脉注射的NP在瘤中迅速积累,通过线粒细胞衰变激活全身抗癌免疫力.
与对照组相比,OPDEA-PCL/ICT NP实现了60%的瘤抑制率,并将小鼠的生存率几乎翻了一番.

结论:

OPDEA-PCL纳米颗粒配方显著提高了Icaritin在HCC的生物可用性和治疗疗效.
这种方法增强了ICT介导的线粒和ICD,从而产生强大的全身抗癌免疫性和改善生存率.
开发的纳米药物为推进HCC免疫疗法提供了一个有前途的战略.

关键词:

癌症免疫疗法免疫疗法肝细胞癌是肝细胞癌.现在我们来看一下icaritinitin.免疫性细胞死亡免疫性细胞死亡针对线粒体的纳米颗粒.线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.

更多相关视频

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

相关概念视频

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.