输血患者遗传性出血端膜切除症患者的红细胞合免疫:单中心回顾性研究
Alexandra Grudzinski1, Brandon Tse2, Russel Ombao2
1Division of Hematology-Oncology, Department of Medicine, St. Michael's Hospital, Unity Health Toronto, 30 Bond Street, Toronto, ON M5B 1W8, Canada.
概括
遗传性出血端膜切除症 (HHT) 患者的红细胞 (RBC) 免疫率高 (36.5%),主要针对Rh和Kell抗原. 这支持在输血HHT个体中对这些抗原进行预防性匹配.
科学领域:
- 血液学 血液学 血液学
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 遗传性出血性电脉切开症 (HHT) 是一种遗传性血管疾病.
- 高血压可能导致慢性出血,需要输血红细胞 (RBC).
- 关于HHT患者的输血需求和并发症的数据有限.
研究的目的:
- 调查红细胞输血需求和HHT患者的免疫率.
- 在输血HHT患者中识别常见的RBC配方抗体.
- 为HHT患者提供输血策略的信息.
主要方法:
- 在圣迈克尔医院 (2011-2020年) 成年HHT患者的回顾性图表审查.
- 包括确诊的HHT诊断,住院检查和输血兼容性测试的患者.
- 从电子医疗记录中提取的数据;使用描述性统计数据.
主要成果:
- 63名HHT患者接受了兼容性测试和输血.
- 输血HHT患者中有36.5%的患者产生了红细胞类抗体,主要是针对Rh和Kell抗原 (Anti-E,Anti-K,Anti-c).
- 除了一个异常值外,每位患者输血的平均红细胞单位为22.1;9.5%的患者发生了输血反应.
结论:
- 在这个HHT队列中,红细胞合免疫率明显高于一般人群.
- 常见的分配抗体 (Rh,Kell) 支持目前的预防性表型匹配政策.
- 这些发现强调了针对HHT患者量身定制的输血协议的重要性.
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