在学前自闭症谱系障碍中右半球的微观结构异常
Ting Yi1, Yuqing Liu1, Weian Wei1
1Department of Radiology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital) , 410007, Changsha, China.
Journal of psychiatric research
|October 25, 2024
概括
扩散基谱成像揭示了自闭症谱系障碍 (ASD) 的学龄前儿童中明显的白质异常. 在右环状回形中,分数异性变异显示为ASD的诊断标志物具有前途.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 自闭症谱系障碍 研究研究
背景情况:
- 自闭症谱系障碍 (ASD) 是一种影响全球儿童的神经发育的疾病.
- 了解自闭症底层神经生物学对于早期诊断和干预至关重要.
- 患有自闭症的学龄前儿童表现出独特的微观结构大脑差异.
研究的目的:
- 研究 ASD 的学龄前儿童半球白质微结构异常.
- 使用扩散基谱成像 (DBSI) 分析大脑白质.
- 识别潜在的成像生物标志物,用于早期发现自闭症.
主要方法:
- 在3T中使用DBSI对35名ASD学龄前儿童和32名健康对照 (HC) 进行了研究.
- 分析了DBSI衍生的白质指数,使用基于通道的空间统计 (TBSS).
- 使用支持矢量机 (SVM) 用于与临床尺度进行分类和相关性分析.
主要成果:
- 自闭症组在右脑干中显示出更高的纤维比率,在左上纵向囊中增加了辐射扩散性.
- 在ASD患者的投影纤维,委托纤维和关联纤维中观察到减少的分数异位性 (FA).
- 右带皮的FA与盖塞尔尺度正相关,实现了90%的ASD鉴定特异性.
结论:
- DBSI的发现表明,在学前儿童的ASD中,右半球和小脑中存在异步髓化.
- 右环状回形的微分异型 (FA) 是学龄前自闭症的潜在可靠生物标志物.
- 这项研究强调了DBSI在识别早期ASD诊断神经生物学标志物的实用性.
更多相关视频
06:15Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism
Published on: October 3, 2018
7.7K
05:32Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
Published on: December 7, 2018
8.9K
相关概念视频
01:19Autism Spectrum Disorder
69
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
69
01:30Attention-Deficit/Hyperactivity Disorder
46
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
46
01:26Modeling in Therapy
49
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
49
01:05Cerebral Hemispheres
301
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
301