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5H-[c]衍生物通过微管不稳定表现出通过微管不稳定抗增殖活性

Eram Fatima1, Yashveer Gautam2, Barsha Thapa3

  • 1CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.

Bioorganic chemistry
|October 25, 2024
PubMed
概括

研究人员合成了新的5H-[c]衍生物,它们对癌细胞具有显著的抗增殖活性. 化合物21表现出强大的抗白血病作用和有希望的体内疗效,具有良好的耐受性.

关键词:
剧烈的口服毒性急性毒性这是一种抗癌药物.类化物 类化物 类化物微管不稳定性的微管不稳定性减少循环的循环化

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