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发现和评估新的SHIP-1抑制剂

Jinmin Miao1, Jianping Lin1, Jiajun Dong1

  • 1Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.

Bioorganic & medicinal chemistry
|October 25, 2024
PubMed
概括

研究人员确定了SHIP-1的新型抑制剂,该基因与阿尔茨海默病风险有关. 化合物SP3-12增强了微细胞化,通过向SHIP-1活动,为AD提供了潜在的治疗途径.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.高通量选的高通量选微质的细胞形成.含有Src同质性2的内醇5′-酸酶-1 (SHIP-1) 的

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