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子甲促进自,通过抑制CXCL12/CXCR4轴来损害子宫内膜分泌

Jiaying Huang¹, Fengxia Liu², Tao Qi²

¹Department of Health Toxicology, School of Public Health, Chongqing Medical University, Chongqing, PR China; Joint International Research Laboratory of Reproduction & Development, Ministry of Education, Chongqing Medical University, Chongqing, PR China; Jiangbei District Center for Disease Control and Prevention, No. 90, Taping, Jiangbei District, Chongqing, PR China.

Chemico-biological interactions

|October 25, 2024

概括

甲 (BaP) 暴露会通过抑制CXCL12/CXCR4通路,诱导细胞自,并损害子宫内膜分泌,导致植入问题来破坏早期怀孕.

科学领域:

生殖毒理学生殖毒理学
细胞生物学细胞生物学
环境健康环境健康

背景情况:

甲 (BaP) 是一种环境污染物,与不良妊娠结果有关.
子宫内膜分泌对于成功的胚胎植入和早期怀孕维护至关重要.
障碍的决定化可能导致植入失败,胎盘异常和妊娠失败.

研究的目的:

调查BaP在怀孕早期中破坏子宫内膜分泌的机制.
探索自和CXCL12/CXCR4轴在BaP诱导的生殖毒性中的作用.

主要方法:

用小鼠模型和实验室内*的果 stromal 细胞 (DSC) 来研究 BaP 的影响.
使用抑制剂 (3-甲基氨酸,氨酸) 和激活剂来调节自.
分析了CXCL12/CXCR4信号通路的激活和下游效应 (PI3K/AKT).

主要成果:

对BaP的暴露抑制了CXCL12/CXCR4的表达,并通过促进DSC中的自细胞形成来诱导自.
在小鼠子宫和DSC中,BaP诱导的自损害了决定化.
自抑制或CXCL12/CXCR4激活部分挽救了BaP诱导的叶损伤,并恢复了基因表达.

结论:

通过抑制CXCL12/CXCR4轴,BaP损害了早期怀孕的脱胎,导致了脱胎层细胞的过度自.
这项研究阐明了BaP的生殖毒性中的一种新型化学介导机制,为胚胎植入调节提供了洞察力.

关键词:

自自是一种自的过程.BaP BaP BaP 在线播放在CXCL12/CXCR4中,决心实现二元化在PI3K/AKT中使用.

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