在中国65岁以上的老年人中,基于Mycobacterium tuberculosis抗原的皮肤测试和干扰素马释放试验之间的协议
Yijun He1, Lingyu Shen1, Jiang Du1
1NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
概括
基于Mycobacterium tuberculosis (MTB) 抗原的皮肤测试 (TBST) 与中国65岁及以上的老年人进行的干扰素释测试 (IGRA) 有很好的一致性. 这表明TBSTT.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 仍然是一个重要的全球健康问题,特别是在资源有限的环境中.
- 对于潜在的结核病感染,准确的诊断工具对于有效的预防策略至关重要.
- 老年人群对结核病诊断和管理提出了独特的挑战.
研究的目的:
- 评估基于Mycobacterium结核病 (MTB) 抗原的皮肤测试 (TBST) 和干扰素释测试 (IGRA) 之间的一致性.
- 评估TBST在中国老年人 (≥65岁) 中的实用性,超出其标准年龄指示范围.
- 在老年人群中为潜在的结核病查策略提供信息.
主要方法:
- 采用横截面研究设计,利用随机对照试验基线调查的数据.
- 结核菌菌菌 (MTB) 感染同时使用TBST和IGRA进行评估.
- 该研究包括50-70岁的农村居民,特别关注65岁以上的子组.
主要成果:
- 总共有21,219名参与者被分析,显示TBST和IGRA之间的总体一致性为89.4% (kappa=0.61).
- 在65岁以上的个体中,一致性为86.5% (kappa=0.55),表明了实质性的协议.
- 具有不确定的IGRA结果的参与者的显著比例 (21.2%) 通过TBST呈阳性,其中包括9名老年人.
结论:
- 在中国的老年人 (≥65岁) 中,TBST显示与IGRA一致一致.
- 这些发现表明TBST在老年人中的潜在适用性,甚至超出了标记的年龄范围.
- 对发生的结核病纵向数据的进一步分析将为每个测试的诊断性能提供见解.
相关概念视频
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