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溶解介质pH值和药物的电离状态对无形固体分散物的释放性能的影响

Anura S Indulkar1, Samantha Alex1, Geoff G Z Zhang1

  • 1Small Molecule CMC Development, Research and Development, AbbVie Inc., North Chicago, IL 60064, United States.

Journal of pharmaceutical sciences
|October 25, 2024
PubMed
概括

溶解介质的pH显著影响可电离药物的无形固体分散 (ASD). 电离增强药物释放,并允许在ASD中增加药物负载,改善口服生物可用性.

关键词:
无形固体的分散性固体.阿塔萨纳维尔 (atazanavir) 是一种药物.一致性是一致性.解散 解散 解散 是一个过程.电离化的电离.这就是LoC LoC.聚乙烯酸乙烯酸 (PVPVA) 是一种聚乙烯酸乙烯酸 (PVPVA)释放 释放 释放 释放它们的pH值为pH.

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