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Updated: Jun 9, 2025

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
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Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

Published on: June 9, 2017

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由DNA损伤引起的p53通过一个涉及miR-34a和FOXP1的负反循环降低RAG1的表达

Katarina Ochodnicka-Mackovicova1, Martine van Keimpema1, Marcel Spaargaren2

  • 1Department of Pathology, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, The Netherlands; Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands.

The Journal of biological chemistry
|October 25, 2024
PubMed
概括

DNA损伤触发了p53介导的反循环,该循环会降低B细胞发育中的重组激活基因1 (RAG1) 的下调. 这一过程涉及microRNA-34a,在V(D) J重组过程中保护基因组稳定性.

关键词:
这是一个ATMATMATM.在B细胞白血病中.造成的DNA损伤是DNA损伤.这就是FOXP1P.在RAG1中,RAG1是RAG1的第一个重点.在RAG2的基础上,RAG2是RAG2.在VDJ重组的过程中,VDJ重组反法规反法规的规定.在 miR-34a 中使用.在 p53 里,p53 是一个 p53 的类型.在pre-B细胞中.

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