评估晚间低血糖症老年患者的潜在上腺功能缺陷:一项回顾性观察性研究
Ken Kanazawa1, Mai Hijikata1, Koichiro Kuwabara1
1Departments of Diabetes, Metabolism and Endocrinology, Japan Organization of Occupational Health and Safety, Tokyo Rosai Hospital, Tokyo, Japan.
概括
夜间低血糖 (NH) 与65岁以上老年患者的潜在上腺功能不足 (LAI) 有显著的关联. 在NH患者中早期诊断和治疗LAI可以预防严重的健康并发症.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 夜间低血糖 (NH) 是糖尿病老年患者的常见问题.
- 潜在上腺功能缺陷 (LAI) 是一种被诊断不足的疾病,可能会加剧代谢障碍.
- 在老年人群中NH和LAI之间的关系需要进一步研究.
研究的目的:
- 为了评估夜间低血糖 (NH) 和潜在上腺功能不足 (LAI) 在65岁以上的个体之间的关联.
- 确定患有NH的老年患者中LAI的患病率.
- 评估在这个人口群体中诊断LAI的临床影响.
主要方法:
- 一项追溯观察性研究,涉及2017年11月至2020年2月期间的1238名老年患者 (>65岁).
- 持续血糖监测 (Freestyle Libre Pro) 用于评估430名未评估LAI的患者的NH.
- 倾向性得分匹配用于创建可比的组进行分析,包括192名患者 (每组96名).
主要成果:
- NH的总体发病率为28.8%.
- 新诊断和疑似LAI的患病率在NH组 (26.04%) 与非NH组 (12.5%) 相比显著更高 (OR:3.26,P <.001).
- 与没有LAI的老年患者相比,患有NH和新诊断的LAI的老年患者患低血糖的发病率更高.
结论:
- 在老年人中,夜间低血糖和潜在上腺功能不全之间存在显著的关联.
- 在NH的老年患者中诊断和治疗LAI可以预防严重并发症并改善预期寿命.
- 这项研究强调了在经历夜间低血糖症的老年人中对LAI进行查的重要性.
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