针对不同合格动脉的症状性内动脉狭窄的支架:预先计划的个人患者数据分析
Tianhua Li1, Jichang Luo1, Xuesong Bai1
1Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China.
Stroke and vascular neurology
|October 25, 2024
概括
皮肤透光血管塑造和支架 (PTAS) 增加了基底动脉狭窄的中风风险. 对于内动脉,中脑和脊椎动脉狭窄,PTAS在医疗管理上没有显著的优势.
科学领域:
- 神经学 神经学
- 干预心脏病学 干预心脏病学
- 血管外科 血管外科
背景情况:
- 症状性内动脉狭窄症 (ICAS) 治疗疗效因动脉而异.
- 皮肤透光血管整形和支架 (PTAS) 与ICAS的医疗管理进行了比较.
研究的目的:
- 评估PTAS与治疗症状性ICAS在内动脉 (ICA),中脑动脉 (MCA),脊椎动脉 (VA) 和基础动脉 (BA) 的医学疗法的疗效.
主要方法:
- 来自两个随机对照试验的个体患者数据的聚合分析.
- 主要结局:中风或30天内死亡,或区域性中风长达1年.
- 使用危险比率 (HR) 和95%置信区间 (CI) 的治疗意图方法.
主要成果:
- 分析了809名患者;400人接受PTAS,409人接受医学治疗.
- 显著更高的中风风险与PTAS的症状基础动脉 (BA) 狭窄 (17.17%对7.77%;HR,2.38).
- 在PTAS和ICA,MCA和VA狭窄症的医疗治疗之间,中风风险没有显著差异.
结论:
- 在症状性BA狭窄症中,PTAS显著增加了短期和长期中风风险.
- 在没有技术进步的情况下,PTAS在BA狭窄方面提供了有限的好处.
- 对于症状性ICA,MCA和VA狭窄症的医学治疗,PTAS没有显著的优势.
关键词:
缺血性中风 缺血性中风
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