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Updated: Jun 9, 2025

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在阿尔茨海默氏病中,底层的分子机制 氨基酸β介导血管细胞粘附分子-1的升调

Vrishali S Salian1, Xiaojia Tang1, Kevin J Thompson1

  • 1Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (V.S.S., K.K.K.); Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota (G.L.C., V.J.L.); Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota (X.T., K.J.T., K.R.K.); and Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (L.L.).

The Journal of pharmacology and experimental therapeutics
|October 25, 2024
PubMed
概括

阿尔茨海默病涉及到脑血管炎症. 胺β 42 (Aβ42) 暴露会通过 Src/p38/MEK 途径增加血管细胞粘附分子-1 (VCAM-1) 在血脑屏障上,从而提供新的治疗点.

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