在资源丰富的环境中,Shigella物种的流行病学和抗菌素耐药率
Samuel Baumgart1, Thuy Phan2, Genevieve McKew3
1Department of Microbiology and Infectious Diseases, Concord Repatriation General Hospital, NSW Health, Concord, NSW, Australia.
Pathology
|October 25, 2024
概括
石病是一种严重的腹疾病. 在全球范围内,Shigella细菌的抗生素耐药性正在增加,多药耐药 (MDR) 和广泛耐药 (XDR) 菌株的检测率更高.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 石病是导致腹疾病,发病率和死亡率的全球重要原因之一.
- 多耐药 (MDR) 和广泛耐药 (XDR) 菌株的出现,在全球范围内构成了日益严重的公共卫生威胁.
- 监测局部耐药性模式对于有效的实证抗生素治疗策略至关重要.
研究的目的:
- 分析十多年来西格拉菌群中抗菌素耐药性的趋势.
- 评估多药耐药 (MDR) 和广泛耐药 (XDR) 的西格拉菌种的流行情况.
- 根据不断变化的耐药性模式,为管理石病提供临床指导方针.
主要方法:
- 追溯性实验室研究分析便分离物.
- 数据收集时间为10年 (2013-2023年).
- 在Shigella分离物上进行的抗微生物敏感性测试.
主要成果:
- 显著增加了对第三代化素的耐药性.
- 观察到对阿齐思罗米和西普罗夫洛克萨的抗药性增加.
- 记录了MDR和XDR西格拉分离物流行率的整体增加.
结论:
- 这项研究突显出一种令人担忧的趋势,即西格拉菌中抗菌素耐药性增加.
- 对关键抗生素的耐药性增加需要更新治疗指南.
- 持续监测Shigella流行病学和耐药性对于公共卫生至关重要.
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