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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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Overview
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骨老化和细胞外囊泡的发生.

Jian Wang1, Yuanwei Zhang2, Sicheng Wang3

  • 1Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Trauma Orthopedics Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Musculoskeletal Injury and Translational Medicine of Organoids, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; School of Medicine, Shanghai University, Shanghai 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai 200444, China.

Science bulletin
|October 25, 2024
PubMed
概括
此摘要是机器生成的。

细胞外囊泡 (EVs) 通过影响骨代谢,在骨老化中发挥关键作用. 研究强调了它们作为骨健康的生物标志物和治疗剂的潜力.

关键词:
生物标志物生物标志物骨老龄化 骨老龄化 骨老龄化骨的新陈代谢 骨的新陈代谢骨再生 骨的再生细胞外囊泡中的细胞外囊泡.

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科学领域:

  • 骨生物学和老年学
  • 细胞和分子医学 细胞和分子医学

背景情况:

  • 骨质衰老的特点是骨质量和强度下降,这是一个重要的全球健康问题.
  • 细胞外囊泡 (EVs) 是细胞衍生的粒子,参与生理过程和与年龄有关的疾病.
  • 电动汽车与骨老化的相互作用,特别是它们对骨代谢的影响,是研究的一个关键领域.

研究的目的:

  • 在骨老化的背景下,审查EVs的生物学,类型和功能.
  • 检查EVs在骨代谢和衰老中的调节作用.
  • 探索EVs作为生物标志物和治疗与年龄相关的骨疾病的治疗剂的潜力.

主要方法:

  • 关于电动汽车和骨老化的当前研究的综合文献综述.
  • 对研究EV对骨代谢的影响的研究分析.
  • 检查EV在骨健康中的现有和潜在的治疗应用.

主要成果:

  • EVs显著调节骨代谢,并与骨衰老的进展有关.
  • 电动车显示出作为可靠的生物标志物来监测骨衰老的前景.
  • 基于EV的疗法为向药物输送和骨再生提供了潜在的潜力.

结论:

  • 细胞外囊泡代表了理解和管理骨老化的转变领域.
  • 进一步研究基于电动汽车的个性化医学和与先进技术的整合对于改善骨健康至关重要.
  • 解决技术和监管方面的挑战对于EV疗法的临床转化至关重要.