儿科类固醇诱导的眼睛高血压的危险因素
Fumio Takano1, Kaori Ueda2, Yuko Yamada-Nakanishi1
1Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
概括
在儿童中,类固醇诱导的眼睛高血压 (SIOH) 与年轻的年龄,男性性别和较高的类固醇剂量有关. 在治疗期间,监测眼内压力和白细胞数量至关重要.
科学领域:
- 儿科眼科医生 儿科眼科医生
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 类固醇诱导的眼睛高血压 (SIOH) 是一种已知的皮质类固醇治疗并发症.
- 关于儿科SIOH的危险因素的研究有限.
研究的目的:
- 为了确定与儿童SIOH相关的风险因素.
- 分析预测儿科患者类固醇反应的变量.
主要方法:
- 从接受全身类固醇的20岁以下78名儿童回顾性数据收集.
- 分析年龄,性别,原发性疾病,眼内压力 (IOP) 变化,类固醇剂量和血细胞计数.
- 多变量和接收器运行特征 (ROC) 分析以确定风险因素和截止值.
主要成果:
- 38.5%的患者发生了SIOH.
- 年龄较小,男性性别,原发性疾病,白细胞 (WBC) 数量增加,每体重每月总类固醇剂量较高是显著的危险因素.
- 在ROC分析中,确定了年龄 (11.0岁),月均总类固醇剂量 (40.7毫克/公斤) 和白细胞增加 (3.40 × 102/μl) 的截止值.
结论:
- 在更年轻的男性儿科患者中,高剂量类固醇的使用需要对IOP进行警的监测.
- 在后续评估期间,建议与IOP一起监测WBC数量.
- 识别有风险的儿童可以指导系统性类固醇治疗期间眼科检查的频率.
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