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Updated: Jun 9, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

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轴性性α-玻利尔-homoallenyl 烯酸乙作为通用工具箱,用于访问中心和轴性性分子

Yonghoon Jin1, Junseok Lee1, Woohyun Jo1

  • 1Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.

Nature communications
|October 25, 2024
PubMed
概括

这项研究引入了一种新型的铜介导反应,用于合成奇拉性α-boryl-homoallenyl boronic esters. 这些化合物作为多样化的性分子的多功能前体,扩大合成的可能性.

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Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
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