酒精消费对寿命的影响:欧洲人的孟德尔式随机化研究
Zhu Liduzi Jiesisibieke1, C Mary Schooling2,3
1School of Public Health, The University of Hong Kong Li Ka Shing Faculty of Medicine, 7 Sassoon Road, Pokfulam, Hong Kong, Hong Kong.
Scientific reports
|October 25, 2024
概括
这项孟德尔的随机化研究发现,饮酒减少了男性和女性的寿命. 这些发现表明,酒精对健康没有任何好处,可能会缩短寿命,支持公共卫生干预.
科学领域:
- 遗传学和公共卫生
- 流行病学 流行病学
- 酒精研究 酒精研究
背景情况:
- 酒精消费很普遍,但与不良健康结果有关.
- 由于观察性研究的局限性,酒精对寿命的确切影响仍在争论中.
- 遗传学研究提供了一种研究酒精与健康之间的因果关系的方法.
研究的目的:
- 用孟德尔随机化来评估酒精消费对寿命的因果关系.
- 研究吸烟和教育对酒精与寿命关系的影响.
- 检查酒精对长寿影响的潜在性别特异性差异.
主要方法:
- 采用孟德尔随机化 (MR) 方法,利用来自GSCAN联盟的饮酒遗传预测因素 (N=2,428,851).
- 应用基因变异对性别特异性全基因组关联研究 (GWAS) 的寿命和英国生物库数据.
- 利用多变量MR调整吸烟和教育,用血压作为控制结果.
主要成果:
- 酒精消费与整体寿命的显著下降有关 (每条记录的饮料/周为-1.09年).
- 在男性 (-1.47年) 中观察到寿命缩短,并且在调整吸烟和教育后仍然存在.
- 正如预期的那样,酒精摄入与血压升高相关,敏感性分析支持了初步研究结果.
结论:
- 酒精消费与寿命缩短有因果关系,但没有明显的好处.
- 这些发现强调了酒精对长寿的有害影响,特别是在男性中.
- 旨在减少酒精消费的公共卫生干预措施有必要改善人口健康.
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