持续的蛋白尿与心血管疾病的发生有关:全国性基于人口的队列研究
Ho Geol Woo1, Moo-Seok Park2, Tae-Jin Song3
1Department of Neurology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Scientific reports
|October 25, 2024
概括
蛋白尿,损伤的标志物,显著增加心血管疾病 (CVD) 的风险. 持续的蛋白尿症带来了最高的风险,即使与改善或进展的病例相比,强调监测脏健康对预防心血管疾病的重要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 蛋白尿是损伤的关键指标,也是心血管疾病 (CVD) 的重要危险因素.
- 了解蛋白尿变化与心血管疾病发生之间的关联对于风险分层和管理至关重要.
研究的目的:
- 研究蛋白尿状态的变化与复合心血管疾病 (CVD) 的发生率之间的关系.
- 评估随着时间的推移与持续,改善和进展的蛋白尿相关的CVD风险差异.
主要方法:
- 利用了2003-2004年和2005-2006年期间接受国家健康检查的1,708,712名参与者的数据.
- 参与者被分为四个蛋白尿症组:正常,改善,进展和持续.
- 使用多变量Cox比例危险模型进行风险评估,平均随访时间为14.2年.
主要成果:
- 共有143,041名参与者患有复合性心血管疾病.
- 所有蛋白尿症组 (持续,进展,改善) 与正常组相比,心血管疾病风险增加 (p < 0.001).
- 持续性蛋白尿为最高心血管疾病风险 (HR: 1.78),其次是进展 (HR: 1.49) 和改善 (HR: 1.32). 改善组的风险低于持续组 (HR:0.75).
结论:
- 蛋白尿的存在和严重程度的变化与复合心血管疾病的发生率有显著的相关性.
- 持续的蛋白尿是心血管疾病的重大风险因素,即使与已经进展或改善的蛋白尿相比.
- 对蛋白尿的监测和管理对于减轻心血管风险至关重要.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
61
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
61
Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Renal Corpuscle
1.7K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.7K
Hypertension III: Clinical Manifestations and Diagnostic Studies
2
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
2
Nephrons
2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Coronary Artery Disease I: Introduction
3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3


