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Updated: Jun 9, 2025

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HNCDrugResDb:一个破译头癌药物耐药性的平台

Akhina Palollathil1, Revathy Nandakumar1,2, Mukhtar Ahmed3

  • 1Center for Systems Biology and Molecular Medicine (CSBMM), Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, India.

Scientific reports
|October 25, 2024
PubMed
概括

抗药性在头癌 (HNCs) 中是一个主要的挑战. 这项研究确定了驱动HNC耐药性的关键分子和途径,创建了用于分析和个性化医学的数据库.

关键词:
化疗 化疗是一种化学疗法.药物耐药性 药物耐药性 药物耐药性头癌是头部和部的癌症.信号通道的信号通道.转录性重编程是一种转录性重编程.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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