传输线模型作为腹腔大动脉动脉瘤患者的数字双胞胎
Donghyeon Kim1, Divyesh Narayanan2, Shih-Hsien Sung3
1Mechanical Engineering, University of Maryland, College Park, MD, 20742, USA.
NPJ digital medicine
|October 25, 2024
概括
一个传输线模型显示了作为监测腹腔大动脉动脉瘤 (AAA) 的数字双胞胎的潜力. 该模型准确地适应了患者数据,并揭示了动脉性质的变化,这表明了个性化的AAA监测能力.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 医学物理 医学物理
背景情况:
- 腹腔大动脉瘤 (AAA) 对健康构成重大风险,需要先进的监测技术.
- 数字双胞胎技术为个性化疾病管理和预测提供了一个有希望的途径.
- 在AAA中了解动脉血动力学对于有效的治疗策略至关重要.
研究的目的:
- 评估输电线模型作为动脉瘤大动脉的数字双胞胎.
- 分析该模型对AAA患者和健康对照患者的动脉波形的适应性.
- 评估内血管动脉瘤修复 (EVAR) 之前和之后模型参数的变化.
主要方法:
- 对一个统一的无损管载荷模型的比较分析,适用于动脉和大腿动脉度波形.
- 包括79名AAA患者和匹配的对照组的数据 (CON).
- 分析了35名AAA患者在EVAR之前和之后的数据.
主要成果:
- 管载荷模型在AAA患者,对照者和EVAR后的患者中证明了对度波形的良好适应.
- 在模型参数中观察到可以从生理学上解释的变化.
- 正常化的脉冲过渡时间和反射系数随AAA增加,并在EVAR后降低.
结论:
- 传输线路模型显示了作为个性化AAA监控的数字双胞胎的潜力.
- 观察到的参数变化与增加的动脉合规性和AAA的惰性降低相关.
- 该模型可以促进腹腔大动脉动脉瘤的非侵入性评估和管理.
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